TABLE 1.
List of transcripts encoding costamere proteins in Mef2A knockout hearts
A total of 55 known costamere-localized genes were analyzed by qRT-PCR. Gene names are listed according to NCBI gene nomenclature. Fold change is shown for each gene in KO relative to wild type normalized to 1. The 12 genes down-regulated by at least 30% relative to wild type and with a p value <0.05 are indicated in bold type.
| Gene | KO |
|---|---|
| AACTININ | 1.09 |
| AFIL | 1.11 |
| ALP | 0.92 |
| ANF | 1.09 |
| ANK2 | 0.52 |
| ANKRD1 | 0.84 |
| BSPECT | 1.06 |
| CALP3 | 0.60 |
| CAPZA1 | 0.73 |
| CAV3 | 0.88 |
| CYPHER | 0.90 |
| DAG-1 | 0.85 |
| DESMIN | 1.12 |
| DMD | 0.67 |
| DMN | 0.99 |
| DTNA | 1.00 |
| DYSBIND | 0.68 |
| FHL2 | 0.52 |
| G-FILAMIN | 1.14 |
| HIC-5 | 0.98 |
| IGF-1 | 0.86 |
| ILK | 0.79 |
| ITGB1 | 1.05 |
| LAMB2 | 0.59 |
| LIMS1 | 0.79 |
| MELUSIN | 0.87 |
| MLP | 0.95 |
| MYOZ1 | 0.78 |
| MYOZ2 | 0.80 |
| MYOZ3 | 1.29 |
| MYPN | 0.98 |
| NEBULIN | 0.92 |
| NNOS | 0.72 |
| OBSCN | 0.54 |
| PARB | 0.89 |
| PAXILLIN | 0.84 |
| PDLIM1 | 0.56 |
| PDLIM5 | 0.63 |
| PDLIM7 | 0.87 |
| PKP2 | 1.17 |
| PLECTIN | 0.97 |
| PTK2 | 0.99 |
| SGCA | 0.69 |
| SGCB | 0.72 |
| SGCD | 0.91 |
| SGCG | 0.64 |
| SNTA | 1.03 |
| SSPN | 0.96 |
| SYNC | 0.85 |
| TALIN | 0.81 |
| TCAP | 0.51 |
| TITIN | 0.74 |
| TTID | 1.14 |
| UTRN | 1.01 |
| VINCULIN | 0.87 |
| ZYXIN | 1.20 |