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A simplified pathway to depict the TPA-induced MnSOD expression in A549 cells. Here TPA was shown to activate PKC-α, which in turn phosphorylates the CREB transcription factor, and PKC-ϵ, which induces the formation of PP2A-pAkt complex to facilitate the dephosphorylation of pAkt and subsequently lead to the accumulation the dephosphorylated and active FOXO3a.
