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Mutants of human AChE created and tested in this study. Mutated residues in the active center gorge of hAChE (PDB code 3LII) are highlighted in yellow. Non-aged soman conjugate attached to the active Ser-203 rendered in white (C), orange (P), and red (O) sticks is overlaid into hAChE from the soman inhibited Torpedo californica AChE structure (PDB code 2WG2).
