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Patient mutations mapped onto the MeCbl·t-CblC structure. Residues are shown in ball-and-stick representation with those colored red representing residues involved in Cbl binding or structural integrity. The functions of residues in black are not obvious, and we speculate that Arg-73, due to its surface exposure, might be involved in protein-protein interactions, whereas Arg-161 might be involved in GSH binding due to its vicinity to the putative GSH binding site.
