TABLE 2.
TGF-β-induced genes with Smad2/3 and HNF4α binding at 1.5 h
Target genes of TGF-β in HepG2 cells that were induced more than 2-fold at 1.5 h and that have common binding regions for Smad2/3 and HNF4α were sorted by their expression changes in the presence or absence of HNF4α siRNA. Presence of Smad2/3 binding regions in HaCaT cells is also shown in the 2nd column.
| Gene symbol | Smad2/3 binding in HaCaT cells | Relative expression (siNC/siHNF4α) | Induction by TGF-β |
|---|---|---|---|
| -fold | -fold | ||
| CMIP | + | 0.3 | 2.1 |
| REPIN1 | + | 0.3 | 2.2 |
| MIXL1 | − | 0.3 | 2.3 |
| ERRFI1 | + | 0.4 | 2.7 |
| FASTK | + | 0.5 | 2.1 |
| ZNF48 | − | 0.5 | 2.6 |
| CBX4 | − | 0.6 | 2.2 |
| TMEM49 | − | 0.8 | 2.1 |
| ZFP36L2 | − | 0.9 | 2.6 |
| JUNB | + | 1.0 | 9.8 |
| DDIT4 | + | 1.1 | 5.6 |
| GADD45B | + | 1.3 | 4.9 |
| RND1 | − | 1.4 | 5.5 |