TABLE 1.
Serum parameters measured in 6-month-old mice fasted overnight
FFA, free fatty acid; ALT, alanine transaminase; AST, aspartate aminotransferase; LDL, low density lipoprotein; HDL, high density lipoprotein; ND, not determined. n = 8–11 mice per group. *, p < 0.05; **, p < 0.01; ***, p < 0.001 for WT versus HBxTg mice. #, p < 0.05; ##, p < 0.01; ###, p < 0.001 for HBxTg versus HBxTg/iNOS−/− mice. Data are expressed as means ± S.E.
| Parameter | WT | HBxTg | HBxTg/iNOS−/− |
|---|---|---|---|
| Triglyceride (mg/dl) | 78 ± 1.1 | 113 ± 2.6*** | 95 ± 5.6## |
| Cholesterol (mg/dl) | 120 ± 2.8 | 196 ± 3.7*** | 161 ± 5.2### |
| FFA (μmol/liter) | 1.156 ± 0.046 | 1.766 ± 0.043*** | 1.964 ± 0.107 |
| Serum insulin (ng/ml) | |||
| Fasted | 1.101 ± 0.182 | 0.340 ± 0.070 | 0.280 ± 0.015 |
| Fed | 1.842 ± 0.366 | 1.095 ± 0.235 | 1.010 ± 0.344 |
| Serum glucagon (pg/ml) | 414 ± 26 | 535 ± 27* | 458 ± 27 |
| ALT (unit/liter) | 41 ± 3.8 | 51 ± 2.8** | 43 ± 3.6 |
| AST (unit/liter) | 51 ± 5.1 | 83 ± 7.2* | 73 ± 5.6 |
| HDL (mg/dl) | 74 ± 4 | 89 ± 7** | ND |
| LDL (mg/dl) | 7 ± 2 | 12 ± 3* | ND |
| Adiponectin (μg/ml) | 23.3 ± 0.35 | 15.1 ± 0.23* | 18.9 ± 0.18# |