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. 2011 Jun 27;286(34):29882–29892. doi: 10.1074/jbc.M111.259663

FIGURE 7.

FIGURE 7.

Localization of PK cleavage sites in shark Na,K-ATPase. A, sketch showing the localization of PK cleavage sites as determined in shark Na,K-ATPase (red) and from investigations using SERCA1a (25, 27). The numbers in parentheses refer to the SERCA sequence. According to the sketch the p95 peptide is the large fragment resulting from cleavage at K162, the p55 peptide runs from E278 to either I749 or V762 (both sites are cleaved in SERCA), and the p30 peptide results from cleavage of p55 at S375, just before the phosphorylation site (circled P), and at V603. Five of the cleavage sites, except the sites at V603, I749, and N838 (I611, V734, and D818 in SERCA), are conserved between SERCA and Na,K-ATPase. B, a ribbon model of the cytoplasmic part of the shark Na,K-ATPase (the stippled frame in panel A) with the cleavage sites indicated in stick presentation. N838 is the tryptic cleavage site giving rise to the C-terminal 19 kDa peptide. The N-, P-, and A-domains are indicated.