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Proposed model. Galectin-3 promotes clustering of VEGF-R2 by binding to Mgat5-synthesized β1,6GlcNAc-branched N-glycans. In the absence of galectin-3, VEGF receptors accumulate in endosomal vesicles (left panel). In the presence of galectin-3, VEGF-R2 is retained on the plasma membrane and angiogenic signaling is enhanced (right panel).
