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. 2011 Jun 24;286(34):30022–30033. doi: 10.1074/jbc.M111.261206

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© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 7. — Myelin degeneration. A, electron micrograph from the midbrain of a 7-month-old CerS2-null mouse. Detachment (left-hand panel) and breakdown (right-hand panel) of the myelin sheath are observed. Scale bars, 0.5 μm for the left-hand panel and 0.2 μm for the right-hand panel. B, Western blots of MBP and PLP. Brain extracts from WT and CerS2-null mice brains at different ages: postnatal day 15 (P15), postnatal day 30 (P30), 2 months (2M), 5 months (5M), and 8 months (8M). Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) acts as a loading control. C, -fold change in levels of MBP and PLP in CerS2-null versus WT mice (obtained by densitometry); values are normalized to GAPDH levels. Values are means ± S.D. (n = 2–3). *, p < 0.05.