TABLE 1.
Astrogliosis in brain regions of the CerS2-null mouse
| Brain area | Intensity of GFAP labelinga |
|---|---|
| Cortex | |
| Motor | ++ |
| Sensory | ++ |
| Piriform | ++ |
| Auditory | + |
| Occipital | − |
| Basal ganglia | |
| Caudate putamen | ++ |
| Nucleus accumbens | + |
| Globus pallidus | +++ |
| Substantia nigra | ++ |
| Hippocampus | |
| CA1 | − |
| CA2/CA3 | − |
| Hippocampal fissure | ++ |
| Dentate gyrus | − |
| White matter tracts | |
| Anterior commissure | ++ |
| Corpus callosum | +++ |
| Fimbria | +++ |
| Internal capsule | +++ |
| Cerebellum (white matter) | +++ |
| Other regions | |
| Thalamus | ++ |
| Midbrain | ++ |
| Amygdala | ++ |
| Olfactory bulb | − |
a The number of plus signs indicates the extent of GFAP immunoreactivity in the CerS2-null mouse compared with the WT with “−” indicating no change, “+” indicating a few more GFAP-positive cells, and “+++” indicating extensive numbers of GFAP-positive cells.