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. 2011 Jun 10;301(3):H794–H802. doi: 10.1152/ajpheart.00425.2011

Fig. 4.

Fig. 4.

Downstream calcium fluorescence entails activation of luminal muscarinic receptors. A: representative trace of fluorescence changes (F/Fo) vs. time recorded 500 μm downstream of the ACh stimulus. Each tick of x-axis = 1 s. First break (↓) indicates 3–5 min equilibration following retroorbital injection of glycopyrrolate into the bloodstream. Second break (↑) indicates 60-min recovery. Note robust calcium fluorescence response under control conditions, inhibition within several min of intraluminal muscarinic receptor inhibition, and response recovery after 60 min. B: summary data for glycopyrrolate treatment (Glyco) and recovery (n = 5). *P < 0.05, significantly different from control. #P < 0.05, significantly different from Glyco.