Fig. 7.
Appearance of DADs diminished or delayed with reduced sensitivity to CaSR and CaDyad. The top and middle top rows (1) show membrane voltage and RyR open probability (ORyR; original results as dashed lines) for the scenarios where the sensitivity of gating dynamics to CaSR (gray solid lines) and CaDyad (black solid lines) was reduced for three different models showing DADs. The middle bottom and bottom rows (2) additionally include the sensitivity to the driving force (CaSR-CaDyad) of the RyR current. A–C: results for the Fink08 (A), Matsuoka03 (B), and Shannon04 (C) models. When only gating dynamics are considered, the appearance of DADs was more sensitive to CaDyad in these models. When the driving force for RyR was included, the results were more similar for both Ca2+ compartments and overall inconclusive.