Table 2.
Overview of grouping of the investigated mathematical cell models according to their origin and Ca2+ subsystem structure
| Base model | Derived models | RyR Model Type |
|---|---|---|
| DiFrancesco85 (16) | Other | |
| Hilgemann87 (27) | Earm90 (17), Lindblad96 (48) | M + voltage dependence |
| Noble91 (63) | Noble98 (65)*, Espinosa98 (18), Noble01 (66) | M |
| Jafri98 (36) | Winslow99 (101), Pandit01 (71)*, Iyer04 (35) | M |
| Nygren98 (68) | Maleckar09 (54)* | M |
| Matsuoka03 (57)* | Iribe06 (32)* | M + ICaL additive + CaSR modulation |
| Hinch04 (28)* | M + ICaL additive + CaSR modulation | |
| Shannon04 (82)* | Grandi10 (25) | M + CaSR modulation |
| tenTusscher06 (91) | Fink08 (21)*, Stewart09 (88) | HH + CaSR modulation |
| Iyer07 (34)* | M + CaSR modulation | |
| Pasek08 (73)* | M + tubular Ca2+ | |
| Luo-Rudy91 (51) | Luo-Rudy94 (52), Priebe98 (75), Viswanathan99 (97), Faber00 (19) | Not physiological |
| Courtemanche98 (11) | Fox02 (22), Hund04 (30), tenTusscher04 (90), Livshitz07 (50), Mahajan08 (53), Aslanidi09 (3), Decker09 (13) | HH + ICaL multiplied |
| Bondarenko04 (6) | M + ICaL multiplied |
*
Models were used in this article as representative of their group. M, Markov model type; CaSR, Ca2+ in the SR; HH, Hodgkin-Huxley type model.