Table 4.
In vivo hemodynamics
| Control | AB-4m | Ab + DeAb | I/R-2m | MI-2m | Ab + I/R | AB + I/R + DeAb | |
|---|---|---|---|---|---|---|---|
| n | 8 | 7 | 7 | 9 | 9 | 10 | 10 |
| Heart rate, beats/min | 328 ± 7 | 363 ± 25 | 372 ± 7 | 382 ± 16 | 329 ± 7 | 331 ± 12 | 344 ± 13 |
| Minimum pressure, mmHg | 3 ± 1 | 6 ± 0* | 5 ± 1 | 4 ± 0 | 4 ± 1 | 4 ± 1 | 2 ± 1 |
| EDP, mmHg | 8 ± 1 | 10 ± 2 | 9 ± 2 | 6 ± 1 | 8 ± 1 | 10 ± 3 | 7 ± 1 |
| Tau (Weiss), ms | 9.4 ± 0.3 | 8.5 ± 0.6 | 8.3 ± 0.2 | 8.3 ± 0.3 | 10.2 ± 0.5 | 10.2 ± 0.7 | 9.0 ± 0.3 |
| Stroke volume, μl | 187 ± 19 | 99 ± 11** | 164 ± 19 | 130 ± 6 | 95 ± 7** | 102 ± 7** | 151 ± 20 |
| CO, ml/min | 60.5 ± 5 | 37.5 ± 5** | 60.9 ± 7 | 63.3 ± 8 | 31.4 ± 3** | 36.3 ± 3* | 58.5 ± 7 |
| EDPVR slope | 0.04 ± 00 | 0.09 ± 0.01 | 0.06 ± 0.01 | 0.06 ± 0.01 | 0.08 ± 0.02** | 0.16 ± 0.02** | 0.06 ± 0.2 |
| EDPVR intercept | −9 ± 24 | 126 ± 25 | 72 ± 28 | 168 ± 14 | 108 ± 29 | 128 ± 17 | 177 ± 33 |
| Emax, mmHg/μl | 2.0 ± 0.53 | 4.4 ± 1.14* | 3.4 ± 0.98 | 3.3 ± 0.42 | 1.8 ± 0.34 | 7.2 ± 1.42 | 3.2 ± 0.63 |
| Ea, mmHg/μl | 0.67 ± 0.06 | 2.34 ± 0.23** | 1.02 ± 0.11 | 0.83 ± 0.10 | 1.00 ± 0.12 | 1.32 ± 0.26* | 0.74 ± 0.12 |
Values are means ± SE; n, no. of rats. EDP, end diastolic pressure; Tau, time of isovolumic relaxation; CO, cardiac output; EDPVR, end diastolic pressure-volume relationship; Emax, maximal ventricular systolic elastance; Ea, arterial systolic elastance.
*
P < 0.05 and
**
P < 0.01 compared with control.