Table 1. Patient characteristics in HlV-associated Merkel cell carcinoma.
Case (reference) | Sex | Race | Age at MCC diagnosis (years) | MCC site | HIV diagnosis to MCC (years) | CD4 cell count (cells/μl) | Viral load (copies/ml) | Treatment of MCC | on HAART? | Survival (months) |
---|---|---|---|---|---|---|---|---|---|---|
1 [5] | M | NA | 47 | Right buttock | HIV after MCC | 625 | NA | Chemotherapy | No | Recurrence at 11 |
2 [4] | M | NA | 60 | Nose | NA | 329 (2 years after diagnosis) | NA | Mohs radiation therapy | Yes | 24 |
3 [7] | M | NA | 63 | Forehead | 12 | 232 | Undetectable | Mohs | Yes | NA |
4 [8] | M | W | 54 | Left upper extremity | HIV after MCC | 82 | 250000 | WLE | Yes (after diagnosis) | 25 |
5 [6] | M | NA | 51 | Right buttock | 6 | 122 | 32000 | Local radiation therapy (refused surgery) | Yes (×5 months) | 9 |
6 [9] | M | NA | 57 | Right dorsal middle finger | 14 | 357–573 (last 3 years) | Undetectable | WLE | NA | >40 |
7 [10] | F | African black | 36 | Left ear | NA | 63 | 24000 | WLE | Yes | >9 |
8 [11] | M | NA | 48 | Buttock | 10 | 267 | >750000 | WLE, radiation therapy | Yes (after diagnosis) | >11 |
9 [12] | M | Italian | 40 | Left inguinal lymph node (no known skin primary) | 3 | 160 | 11000 | WLE | Yes | >42 |
10 [13] | F | African black albino | 25 | Right cheek | NA | 332 | 187000 | Chemotherapy, radiation therapy, WLE | Yes (after diagnosis) | 12 |
11 [14] | M | W | 48 | Scalp | 12 | Normal | Undetectable | WLE, radiation therapy | Yes | >12 |
12* | M | W | 46 | Right buttock | HIV after MCC | 74 (21 months after diagnosis) | <75000 | WLE, radiation therapy | Yes (after diagnosis) | 23 |
13* | F | W | 52 | Right buttock | NA | NA | NA | WLE, radiation therapy | NA | 12 |
14* | M | W | 58 | Left forearm | HIV after MCC | 421 | 40000 | WLE, lymphadenectomy, chemotherapy, radiation therapy | Yes (after diagnosis) | 18 |
F, female; HAART, highly active antiretroviral therapy; M, male; MCC, Merkel cell carcinoma; NA, not available; W, whites; WLE, wide local excision.
Cases obtained from the data and specimen repository at the Fred Hutchinson Cancer Research Center.