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. Author manuscript; available in PMC: 2012 Sep 15.
Published in final edited form as: Environ Sci Technol. 2011 Aug 19;45(18):7896–7905. doi: 10.1021/es200422b

Table 4.

Associations between OH-PBDEs and TH in second trimester pregnant women from Northern and Central California

Free T4 (N=24)
Total T4 (N=23)
TSH (N=24)
β 95% CI β 95% CI β 95% CI
OH-PBDE groupings (ng/mL)
 ΣOH-PBDE4 −0.04 −0.13, 0.05 −0.57 −1.57, 0.44 0.29 −0.05, 0.64#
 ΣTTR binders −0.02 −0.09, 0.06 −0.22 −1.07, 0.63 0.31 0.04, 0.59*
Individual metabolites (ng/mL)
 4′-OH-BDE17 0.00 −0.07, 0.07 0.03 −0.99, 1.05 0.16 −0.13, 0.45
 5-OH-BDE47 0.00 −0.06, 0.05 −0.08 −0.70, 0.55 0.18 −0.03, 0.40#
 6-OH-BDE47 −0.03 −0.10, 0.03 −0.73 −1.48, 0.02# 0.06 −0.22, 0.34
 4′-OH-BDE49 0.00 −0.09, 0.09 0.09 −0.93, 1.11 0.50 0.22, 0.78**
*

p < 0.05;

**

p < 0.01;

#

p < 0.10

Adjusted for lipid content and parity; and total T4 models are additionally adjusted for age.

c

ΣTTR binders is a weighted sum of BDE-47, 5-OH-BDE47, 6-OH-BDE47, and 4′-OH-BDE49. Concentrations are weighted according to their potencies to compete with T4 for binding to transthyretin (TTR) as determined by Hammers et al. [23].