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. 2011 Oct 11;9(10):e1001170. doi: 10.1371/journal.pbio.1001170

Figure 6. Order of evolutionary emergence for the adaptin protein families.

Figure 6

Phylogenetic analysis of a concatenated dataset of β-adaptin and μ-adaptin homologues from diverse eukaryotes, rooted with the β and δ COP homologues. The different complexes are colour coded in the same way as in Figures 1c and 10. AP-3 is demonstrated here to be the earliest diverging adaptor complex, highlighted by the shaded box showing its exclusion from the other AP families. The best Bayesian topology is shown with support values listed in the order of Posterior probability values and ML bootstrap support values for PhyML and RAxML. Numerical values are given for the backbone nodes and for the monophyly of each protein family (illustrated by the shaded boxes). Other values are replaced with symbols as inset.