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. Author manuscript; available in PMC: 2011 Oct 12.
Published in final edited form as: Nat Med. 2010 Aug 22;16(9):1024–1028. doi: 10.1038/nm.2200

Figure 2.

Figure 2

ALDH2i decreases cocaine-induced dopamine (DA) production and increases THP abundance in PC12 cells. (a–e) Cells were incubated with or without cocaine (Coca, 1 μM) in the presence or absence of ALDH2i, the D1 antagonist SCH 23390 (SCH, 10 μM), the D2 antagonist spiperone (SPIP, 10 μM) or THP for 24 h. Intracellular and extracellular dopamine (a,b,e), total dopamine (c) or THP amounts (d) were determined. *P < 0.05, **P < 0.01 compared with cocaine control. (f) Dose-response analysis of THP and α-methyl-L-tyrosine (αMLT) on the inhibition of total tyrosine hydroxylase (TH) or phosphorylated tyrosine hydroxylase (p-TH).