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. Author manuscript; available in PMC: 2011 Oct 12.
Published in final edited form as: Nat Med. 2010 Aug 22;16(9):1024–1028. doi: 10.1038/nm.2200

Figure 4.

Figure 4

ALDH2i increases THP production to inhibit tyrosine hydroxylase activity and decrease dopamine production in VTA in cocaine-addicted rats. (a,b) Dopamine and THP amounts measured in the VTA (a) and nucleus accumbens (b) pooled from the cocaine-seeking rats treated with ALDH2i (I, 15 mg per kg body weight, n = 8) or vehicle (V, n = 8) in Figure 1c or from naive rats treated with ALDH2i (15 mg per kg body weight, n = 8) or vehicle (n = 8). The experiment was repeated with similar results. (c) Tyrosine hydroxylase phosphorylation at Ser40 in the VTA, as detected by western blotting. **P < 0.01 compared with naive vehicle control. (d) The number of lever presses during the 2-h cue-induced cocaine reinstatement session (n = 8, #P < 0.01 compared with extinction; **P < 0.01 compared with Veh).