Table 1.
The genotype and allele frequencies of MNS16A in patients with nasopharyngeal carcinoma and cancer-free controls
| MNS16Aa | Cases, n (%), n = 798b | Controls, n (%), n = 1019b | OR (95% CI)c,d | Pc |
|---|---|---|---|---|
| Alleles, bp | ||||
| 302 (reference) | 1520 (95. 2) | 1903 (93. 4) | 1. 00 | |
| 243 | 44 (2. 8) | 76 (3. 7) | 0. 74 (0. 51 to 1. 08) | 0. 12 |
| 272 | 31 (1. 9) | 59 (2. 9) | 0. 65 (0. 42 to 1. 01) | 0. 058 |
| 333 | 1 (0. 06) | 0 | - | - |
| Genotypes | ||||
| 302/302 (reference) | 724 (90. 7) | 891 (87. 4) | 1. 00 | |
| 243/302 | 41 (5. 2) | 65 (6. 4) | 0. 80 (0. 53 to 1. 20) | 0. 29 |
| 272/302 | 30 (3. 8) | 56 (5. 5) | 0. 64 (0. 41 to 1. 01) | 0. 059 |
| 243/243 | 1 (0. 1) | 4 (0. 4) | 0. 36 (0. 04 to 3. 73) | 0. 41 |
| 243/272 | 1 (0. 1) | 3 (0. 3) | 0. 33 (0. 04 to 2. 94) | 0. 32 |
| 302/333 | 1 (0. 1) | 0 | - | - |
| Group of genotypes | ||||
| LL (reference) | 725 (90. 9) | 891 (87. 4) | 1. 00 | |
| SL | 71 (8. 9) | 121 (11. 9) | 0. 73 (0. 53 to 0. 99) | 0. 037 |
| SS | 2 (0. 2) | 7 (0. 7) | 0. 35 (0. 07 to 1. 69) | 0. 17 |
| SL + SS | 73 (9. 1) | 128 (12. 6) | 0. 71 (0. 52 to 0. 96) | 0. 025 |
| Group of alleles | ||||
| L (reference) | 1521 (95. 0) | 1903 (93. 0) | 1. 00 | |
| S | 75 (5. 0) | 135 (7. 0) | 0. 86 (0. 78 to 0. 96) | 0. 014 |
aOwing to genotyping failure, the actual sample size was 798 and 1019 for the cases and controls, respectively.
bL allele was 302 or 333 bp; S allele was 243 or 272 bp.
cThe odds ratios (ORs) and P values were adjusted for age, gender, tobacco and alcohol use, smoking level, ethnicity and family history.
dConfidence interval.