Table 2.
Some important DNA methylated genes in prostate cancer and associated true positive (TP)* and false positive (FP)* values determined by PCR-pyrosequencing for separating cancer from non-cancer. Adapted from [10] with permission of IOS Press.
| Gene | Cut off (% DNAme ) |
TP* (%) |
FP* (%) |
|---|---|---|---|
| RARB | 20.8 | 100 | 0 |
| GSTP1 | 7.3 | 98 | 0 |
| HIN1 | 26.5 | 98 | 0 |
| APC | 26.5 | 96 | 0 |
| BCL2 | 10.4 | 96 | 3 |
| CCND2 | 7.5 | 92 | 0 |
| CHD13 | 27.5 | 88 | 0 |
| EGFR5 | 35.5 | 96 | 14 |
| NKX2-5 | 32.5 | 88 | 0 |
| RASSF1A | 14.8 | 92 | 7 |
| DPYS | 37.9 | 85 | 0 |
| MDR1 | 26.8 | 85 | 3 |
| PTGS2 | 13.8 | 79 | 0 |
| EDNRB | 33.5 | 77 | 0 |
| MAL | 3.8 | 85 | 14 |
| PDLIM4 | 8 | 75 | 3 |
| HLAa | 6.11 | 74 | 14 |
| TIG1 | 4.8 | 65 | 10 |
| ESR1 | 38.5 | 62 | 7 |
| SLIT2 | 33.5 | 56 | 14 |
| CDKN2A | 35.5 | 40 | 0 |
| MCAM | 1.4 | 45 | 18 |
| SFN | 96.5 | 15 | 3 |
| THRB | 27.5 | 26 | 21 |
| CDH1 | 13.2 | 33 | 14 |
*
True positives are the percentage of prostate cancers correctly separated from non-cancers using the indicated PSQ cutoffs. False positives are the percentage of non-cancers falsely indicated as cancer using the indicated PSQ cutoff.