Fig. 4.

Whole cell voltage-dependent and iberiotoxin-sensitive outward currents in freshly isolated human DSM cells. Human DSM cells were held at −70 mV and then stepped from 0 to +80 mV for 200 ms in 20-mV increments. A: original recordings of whole cell outward currents from a human DSM cell under control conditions and 10 min after application of 200 nM iberiotoxin, a highly specific BK channel inhibitor. The whole cell outward currents were significantly inhibited by iberiotoxin. B: current-voltage relationship of the whole cell outward current in the presence and absence of 200 nM iberiotoxin. Values are means ± SE (n=8 DSM cells; N=8 patients; *P < 0.05; **P < 0.01).