Fig. 8.

Inhibition of the BK channels by iberiotoxin eliminates the spontaneous transient hyperpolarizations and causes membrane potential depolarization in freshly isolated human DSM cells. A: original current-clamp recordings of resting membrane potential in a freshly isolated human DSM cell. Visible are STHs of the resting membrane potential, which were inhibited by 200 nM iberiotoxin. B: inhibition of the BK channel with iberiotoxin (200 nM) caused a statistically significant depolarization of the cell membrane potential in human DSM cells. Values are means ± SE (n=12; N=9; *P < 0.05).