Table 1.
Summary data for the TBKC parameters in freshly isolated human DSM cells
| Vh, mV | Amplitude, pA | Frequency, Hz | Rise Time, ms | Decay Time, ms | n | N |
|---|---|---|---|---|---|---|
| −40 | 5.7±2.2 | 0.22±0.1 | 26.4±10.8 | 10.5±3.8 | 12 | 9 |
| −20 | 11.2±2.9 | 0.29±0.1 | 31.2±8.6 | 28.9±11.3 | 12 | 9 |
| 0 | 18.4±5.1* | 0.6±0.1* | 40.2±8.3 | 33.7±14.1 | 11 | 9 |
| +20 | 29.9±8.4** | 0.86±0.2** | 48.7±8.5 | 49.3±17.7* | 11 | 9 |
| +40 | 32.1±9.0** | 1.78±0.5** | 36.6±3.6 | 53.7±0.4* | 7 | 7 |
Values are means ± SE for transient large-conductance voltage- and Ca2+-activated potassium (BK) current (TBKC) parameters measured at holding voltages (Vh) from −40 to +40 mV. n, No. of individual detrusor smooth muscle (DSM) cells; N, no. of patients. Rise time, time from baseline to peak; decay time, time from peak to baseline.
*
P < 0.05 and
**
P < 0.005 vs. means at Vh=−40 mV.