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Comparison of the iron-transport activities of mouse Zip14 and human DMT1. Uptake of 2 μM 55Fe2+ was measured at pH 5.5 and 7.5 in control oocytes (gray bars) and oocytes expressing mouse Zip14 (black bars) or human DMT1 isoform 1A/IRE(+) (hatched bars) (n = 9–12). ANOVA, P < 0.001; aUnadjusted P = 0.90 cf. control at pH 5.5; bunadjusted P = 0.52 cf. control at pH 7.5; DMT1 at pH 5.5 differed from Zip14 at pH 7.5 (unadjusted P < 0.001).
