Table 3.
Potential targets of miRs-21, -26b, -98, and -1826 and their cellular functions based on computational analysis
| miR | Potential Targets | Putative Cellular Function |
|---|---|---|
| miR-21 | Cofilin-2 (CFL-2) | Actin dynamics (1) |
| Myosin phosphatase and interacting protein (M-RIP) | Myosin light chain dephosphorylation, regulation of actin fibers, and smooth muscle cell (SMC) relaxation (42, 47) | |
| ARHGAP24/p73RHOGAP | Negative regulators of signaling (27, 44, 57) | |
| miR-26b | M-RIP | Myosin light chain dephosphorylation, regulation of actin fibers, and SMC relaxation (30, 60) |
| Myosin phosphatase | Regulation of HVSMC contraction (38, 59) | |
| Sling shot homolog 2 (SSH2) | Activator of cofilin and mediator of actin dynamics (12) | |
| miR-98 | Myosin phosphatase | Regulation of HVSMC contraction (67) |
| Sling shot homolog 1 (SSH1) | Activator of cofilin and mediator of actin dynamics (52) | |
| miR-1826 | CDC42 | Regulation of actin polymerization (40, 48, 71) |
| Calmodulin 2 (CALM2) | Calcium sensor and calcium signal modulator (67) | |
| MAP kinase kinase 1 (MAP2K1) | HVSMC contraction (51) |
Nos. in parentheses, ref. nos.