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Proposed model of endothelial GM-CSF influence on neutrophils adherent to and transmigrating through vascular endothelial cell monolayers. GM-CSF apparently stimulates release of prestored OSM from neutrophil granules and new synthesis of OSM that requires β2 integrin-dependent adhesion of the stimulated neutrophils. Release from granules is a rapid event occurring within minutes and new synthesis is more delayed.
