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. 2011 Aug 27;1(1):e000160. doi: 10.1136/bmjopen-2011-000160

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© 2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/2.0/ and http://creativecommons.org/licenses/by-nc/2.0/legalcode.

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Isolation of meticillin-resistant Staphylococcus aureus (MRSA) and meticillin-sensitive Staphylococcus aureus (MSSA) over a 12-year period: (A) interventions and government initiatives over 12 years, along with rates of isolation of (B) MRSA and (C) MSSA in hospital. Points indicate quarterly rates: solid lines are trends in each time period from negative binomial regression. Denominators are the KH03 overnight bedstay statistic. In (B), the optimal change points for MRSA isolation from each group of isolates is shown (dots) along with the range of change points yielding similar model fits (difference in Akaike Information Criterion<3.84). These change points divide the 12-year period into three periods; rates of isolation in each of these periods are shown for (D) MRSA, (E) MSSA and rates of sampling in (F). Evidence for variation in trends in first versus second and second versus third periods respectively: MRSA blood <0.0001, 0.003; MRSA surface <0.0001, <0.0001; MRSA invasive <0.0001, 0.007; MSSA blood 0.79, 0.70; MSSA surface <0.0001, 0.04; MSSA invasive 0.001, 0.90 (*p<0.01 for the comparison shown).