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. 2011 Aug 9;1(1):e000221. doi: 10.1136/bmjopen-2011-000221

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© 2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/2.0/ and http://creativecommons.org/licenses/by-nc/2.0/legalcode.

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Investigated health conditions or problems per age group. The graph on the top left displays the distribution of health conditions or problems studied in trials that recruited only newborn infants; the top-right graph displays this information for trials that recruited only infants/toddlers; the middle left graph for trials that recruited only children >2 years of age; the middle right graph for trials that recruited newborn infants and infants/toddlers; the lower left graph for trials that recruited infants/toddlers and children >2 years of age; and the lower right graph for trials that recruited newborn infants, infants/toddlers and children >2 years of age. ICD-10, Tenth Revision of the International Classification of Diseases.