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. 2011 Sep 12;1(2):e000184. doi: 10.1136/bmjopen-2011-000184

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© 2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/2.0/ and http://creativecommons.org/licenses/by-nc/2.0/legalcode.

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Within-breath impulse oscillometry selected parameters, R5 (A), R20 (B), X5 (C) and Fres (D), versus respiratory phase according to chronic obstructive pulmonary disease severity (■, Stage I; □, Stage II; ▲, Stage III; ▵, Stage IV, respectively) and healthy subjects (▿). Data are expressed as mean±SD. Two-way ANOVA showed statistical significance among the five groups (R5, p<0.0001; R20, p<0.001; X5, p<0.0001; Fres, p<0.0001).