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Table 1. Summary of some significant Food-Drug Interactions.

Drugs Food Drug-Food Interaction
WARFARIN High-protein diet raise serum albumin levels, decrease in international normalized ratio (INR)
Vegetables containing vitamin k interferes with the effectiveness and safety of warfarin therapy.
Charbroiled decrease warfarin activity
Cooked onions increase warfarin activity
Cranberry juice elevated INR without bleeding in elderly patient
Leafy green vegetables thromboembolic complications may develop
Charbroiled decrease warfarin activity
MONOAMNINE OXIDASES Tyramine-containing food1 hypertensive crisis
PROPRANOLOL Rich protein food serum level may be increased
CELIPROLOL Orange juice the intestinal absorption is inhibited
ACES INHIBITORS Empty stomach absorption is increased
CA2 CHANNEL Grape fruit juice increases the bioavailability
ANTIBIOTICS with milk products2 that complex with some antibiotics and prevent their absorption. reduced bioavailability
ACETAMINOPHEN Pectin delays its absorption and onset
NSAIDS Alcohol can increase risk of liver damage or stomach bleeding
Beverages the c max and auc0-alpha significantly increased3
THEOPHYLINE High-fat meal and grape fruit juice increase bioavailability
Caffeine increases the risk of drug toxicity
ESOMEPRAZOLE High-fat meal bioavailability was reduced
CIMETIDINE, RUPATADINE with food(any type) increase bioavailability
ISONIAZIDE Plantsmedicinal herbsoleanolic acid exerts synergistic effect
CYCLOSERINE High fat meals decrease the serum concentration
ESOMEPRAZOLE High-fat meal bioavailability was reduced
CIMETIDINE, RUPATADINE with food(any type) increase bioavailability
ISONIAZIDE Plantsmedicinal herbsoleanolic acid exerts synergistic effect
CYCLOSERINE High fat meals decrease the serum concentration
GLIMEPIRIDE with breakfast absolute bioavailability
ACARBOSE, at start of each meal maximum effectiveness
MERCAPTOPURINE Cow's milk4 reduce bioavailability
TAMOXIFEN Sesame seeds negatively interferes with tamoxifen in inducing regression of established mcf-7 tumor size but beneficially interacts with tamoxifen on bone in ovariectomized athymic mice
LEVOTHYROXINE Grapefruit juice delay the absorption5
GLIMEPIRIDE with breakfast absolute bioavailability