Figure 12.

(A) Structures of PGF_2α-EA and bimatoprost. (B) Structures of compounds tested for the ability to mobilize Ca²⁺ in RAW264.7 cells and H1819 cells.(115) Note that, in aqueous solution, PG-Gs rapidly equilibrate to form a mixture of the 1- and 2-glyceryl esters, with the 1-glyceryl ester predominating at a ratio of approximately 8:2. In contrast, the stereochemistry of the corresponding amide analogues remains fixed. EC₅₀ values are given for Ca²⁺ mobilization in H1819 cells. NR indicates no response.