Figure 6.

Products of the action of cyclooxygenase on endocannabinoids and related compounds. COX-2 produces PGH₂ as the primary product, plus 11- and 15-HETE as minor products. In the absence of any additional metabolizing enzymes, PGH₂ decomposes to form PGD₂, PGE₂, and HHT. Some or all of these compounds have been identified as products of the metabolism of endocannabinoid-like compounds as indicated above. For NAGly, a HETE-Gly derivative(s) was detected, but the exact position(s) of the hydroxyl group(s) was not determined. Endocannabinoid metabolism (2-AG and AEA) has been demonstrated for human COX-2; however, recombinant murine COX-2 has been used in the majority of these studies.