Table 1.
Cytotoxic effects of the arsenicals in A549 cells after 24 h incubation. Shown are IC70 values for the endpoints cell number and colony forming ability. In case of arsenite, MMAIII, DMAIII, MMAV, and DMAV IC70 values were generated from the data originally published in Ebert et al. 2011 [31]; IC70 values represent the respective inhibitory concentrations of the compounds that are required for 30% reduction of cell number or colony forming ability in vitro.
| Arsenic species | IC70 (cell number) |
IC70 (colony forming ability) |
|---|---|---|
| Arsenite | 57.2 μM | 58.8 μM |
| MMAIII | 5.6 μM | 3.8 μM |
| DMAIII | 5.1 μM | 3.2 μM |
| Thio-DMAV | 12.1 μM | 7.2 μM |
| MMAV | >500 μM | >500 μM |
| DMAV | >500 μM | >500 μM |