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Effect of CBL and SBL catalase on [14C]arachidonic acid (AA) metabolism by microsomes overexpressing CYP2C9. Microsomes were incubated with [14C]AA without catalase (A), with CBL (B), or with SBL (C) catalase (500 U/ml). Metabolites were extracted and analyzed by reverse-phase HPLC. Migration times of EET and DHET standards are noted on each chromatogram.
