Fig. 7.

Effects of XE-991 on suprathreshold responses of pyramidal neurons (sharp electrode recordings in slice preparation). Control data are shown in black, and XE-991 (5 μM) data are shown in gray. A: example of the onset of firing during ramps showing a lower onset frequency in XE-991 (bottom). B: interspike intervals (same data as A) plotted as a function of the current. C: gain-frequency relationship (frequency on log axis) determined by noise stimulation and correlation analysis. The data indicate the average depth of firing rate modulation per unit sine wave current and are normalized by the control value at 2 Hz. XE-991 increased gain below 10 Hz but had little effect at higher frequencies.