Table 1.
Current | τ, ms | n |
---|---|---|
Remaining (after Kv1 and Kv2 block) | 137 ± 23 | 6 |
Linopirdine sensitive (3 μM) | 143 ± 19* | 16 |
XE-991 sensitive (0.5–1 μM) | 206 ± 34* | 11 |
Muscarine/Oxo sensitive | 134 ± 11 | 8 |
ScTx sensitive | 69 ± 21 | 4 |
Kv2.1 antibody sensitive | 75 ± 25 | 4 |
DTX sensitive | 11 ± 1 | 33 |
Values are means ± SE (n = no. of cells) for activation time constant τ at −10 mV. Data for current sensitive to stromatoxin (ScTx; putative Kv2 channels) and for current sensitive to intracellular application of a Kv2.1 antibody (Kv2.1 channels) are from Guan et al. 2007a. Data for current sensitive to α-dendrotoxin (DTX; putative Kv1.1, Kv1.2, and Kv1.6 channels) are from Guan et al. 2006. Muscarine/Oxo sensitive, current sensitive to muscarine (0.3–1 μM) or oxotremorine (10 μM).
P < 0.05, significant difference from whole current or blocker-resistant current.