Fig. 2.

Nanomolar THIP sensitivity is absent in CGCs of δ^−/− mice. A: currents elicited by the indicated concentrations of THIP in wild-type (WT) and δ^−/− granule cells. Responses to ≤1 μM THIP are absent in the δ^−/− neuron. Current blockade by the antagonist gabazine confirms that the responses are GABAR mediated. B: summary histogram indicating mean concentration dependence of THIP currents in wild-type (open bars) and knockout (filled bars) granule cells at the indicated concentrations. Numbers above bars indicate n values; *significant current compared with sham perfusion (P < 0.005).