Table 1.

Summary of THIP concentration response data from oocyte experiments

mRNA Injected	Maximal Current (nA)	EC50 (μM)	Hill Slope	IGABA/ITHIP	n
α6 + β3	429 ± 126	18 ± 6.3	0.78 ± 0.12	0.37 ± 0.07	5
α6 + β3 + δ	155 ± 31*	0.031 ± 0.01†	1.0 ± 0.32	0.51 ± 0.04	10
α6 + β3 + γ2	7091 ± 1936*	92 ± 20*	1.3 ± 0.16*	0.69 ± 0.06*	5
α4 + β3	639 ± 173	22 ± 2.6	0.89 ± 0.10	0.39 ± 0.11	5
α4 + β3+ δ	351 ± 111	0.035 ± 0.009‡	0.99 ± 0.09*	0.55 ± 0.10	10
α4 + β3 + γ2	2972 ± 426§	196 ± 18¶	1.4 ± 0.09*	2.2 ± 0.21†	6
α1+ β2 + γ2	4464 ± 1473	423 ± 58*	1.3 ± 0.07	1.8 ± 0.17	7

Each value represents the mean ± SEM based on THIP concentration-response measurements from n oocytes injected with the indicated mRNAs. I_GABA/I_THIP is the mean response to 1 mM GABA relative to the saturating current elicited by THIP. The α4β3δ values are from the pure pool (see Fig. 5A). Statistically significant differences with the respective α4β3 or α6β3 values are shown, where

^*P < 0.05;

^§P < 0.005;

^†P < 0.0005;

^¶P < 5 × 10⁻⁵; and

^‡P < 5 × 10⁻⁹. For α1β2γ2, statistical comparisons were made to the respective values for α4β3γ2.