Figure 5.

Proportion of patients remaining relapse-free (survival distribution function) over time with quetiapine XR or placebo in patients with schizophrenia (interim ITT population). The final steps after 6 months in the Kaplan-Meier curves are due to a late relapse of a single patient on quetiapine XR at a time when only 2 patients were at risk and to a late relapse of a single patient in the placebo group at a time when no other patient receiving placebo was at risk. Thus, after 6 months’ exposure, Kaplan-Meier curves depend on single events and do not give reliable estimates of the percentage of relapse-free patients.

Peuskens J et al. Prevention of schizophrenia relapse with extended release quetiapine fumarate dosed once daily: a randomized, placebo-controlled trial in clinically stable patients. Psychiatry (Edgemont). 2007;4(11):34–50.³¹ Reproduced with permission from Psychiatry (Edgemont).

Abbreviations: ITT, intention-to-treat; XR, extended release.