Table 2.
Conservation of Tlr4 among six mammalian species, calculated according to region
| Human | Chimp | Baboon | Rat | Mouse | Hamster | |
| Extracellular domain | ||||||
| Human | 100% | |||||
| Chimp | 99.6% | 100% | ||||
| Baboon | 91.5% | 91.5% | 100% | |||
| Rat | 61.3% | 60.7% | 59.4% | 100% | ||
| Mouse | 61.9% | 62.0% | 60.1% | 82.9% | 100% | |
| Hamster | 64.3% | 64.2% | 62.5% | 73.8% | 74.8% | 100% |
| Proximal cytoplasmic domain | ||||||
| Human | 100% | |||||
| Chimp | 99.4% | 100% | ||||
| Baboon | 99.4% | 98.7% | 100% | |||
| Rat | 91.7% | 91.0% | 91.0% | 100% | ||
| Mouse | 90.4% | 89.7% | 89.7% | 98.1% | 100% | |
| Hamster | 91.7% | 91.0% | 91.0% | 97.4% | 95.5% | 100% |
| Transmembrane domain | ||||||
| Human | 100% | |||||
| Chimp | 100% | 100% | ||||
| Baboon | 97.1% | 97.1% | 100% | |||
| Rat | 67.7% | 67.7% | 67.7% | 100% | ||
| Mouse | 70.6% | 70.6% | 70.6% | 91.2% | 100% | |
| Hamster | 73.5% | 73.5% | 73.5% | 79.4% | 79.4% | 100% |
| Distal cytoplasmic domain | ||||||
| Human | 100% | |||||
| Chimp | 100% | 100% | ||||
| Baboon | 50% | 50% | 100% | |||
| Rat | 38.1% | 38.1% | ns | 100% | ||
| Mouse | 26.3% | 26.3% | ns | 63.2% | 100% | |
| Hamster | 40.9% | 40.9% | ns | 40.96% | 45.5% | 100% |
With respect to the human sequence, the extracellular domain is amino acids 1-624; transmembrane domain, amino acids 625-658; proximal cytoplasmic domain, amino acids 659-618; distal cytoplasmic domain, amino acids 619-638. Homology estimates were generated by multiplex FASTA comparison; ns, not significant.