Figure 1.

HSV-2 shedding episode of 17 day duration derived from daily sampling. Each episode on and off therapy was analysed for duration (dotted arrow), initiation to peak regression slope (continuous arrow), peak to termination regression slope (dashed arrow), first positive HSV DNA copy number (open circle), peak HSV DNA copy number (open square), last HSV DNA copy number (open triangle) and presence of re-expansion (second peak, defined as a decrease of ≥0.5 log HSV DNA copies/mL followed by an expansion of ≥0.5 log HSV DNA copies/mL).