Fig. 7.

LOX-1 deletion prevents p38 MAPK phosphorylation, CD11b surface expression, and CXCR2 downregulation after the induction of sepsis. At 2 h after CLP-induced sepsis, p38 MAPK phosphorylation (A) and CD11b (B) and CXCR2 (C) surface expression in blood neutrophils (Ly6G⁺) of wild-type (WT) and LOX-1^−/− mice were examined by FACS. Data represent mean fluorescence intensity (MFI). MFI values were calculated by subtracting isotype control antibody staining from phosphorylated p38, CD11b, or CXCR2 antibody staining. *, P < 0.03 (n ≥ 4).