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. 2011 Jul;79(7):2681–2689. doi: 10.1128/IAI.00009-11

Fig. 3.

Fig. 3.

LOS induces DC maturation and TLR4 activation. (A) TLR4- and MD2-transfected HEK cells were triggered with 1, 10, or 100 ng/ml LOS or E. coli LPS for 16 h. TLR4 activation was determined by analyzing the IL-8 concentration in the supernatant by ELISA. DCs were incubated overnight with indicated concentrations of LOS or E. coli LPS. (B to E) The levels of the costimulatory molecules CD80 (B), CD83 (C), CD86 (D), and MHCII (E) expressed on DCs were measured by FACS analysis. The average mean fluorescence intensity for four donors is shown.