Fig. 5.

Role of TNF-α production from CD8⁺ T cells in oviduct pathological sequelae following vaginal C. muridarum infection. Groups (n = 3) of mice as indicated were challenged with 5 × 10⁴ IFU of C. muridarum on day 0, and macroscopic oviduct dilatation was measured on day 80 after challenge. Each individual marker represents one oviduct, and the mean ± SEM of oviduct diameter per group of mice also is shown. The number of normal oviducts (numerator) and the total number of oviducts evaluated (denominator) per respective group of mice have been indicated in parentheses. *, significant (P ≤ 0.05, chi-square test and ANOVA) difference in incidence and dilatation, respectively, of hydrosalpinx between TNF-α^−/− and C57BL/6 mice and in incidence of hydrosalpinx between TNF-α^−/− and TNF-α^−/− receiving C57BL/6 CD8⁺ T cells. Results are a composite from two independent experiments.