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Proposed model of MCP-1-mediated neutrophil recruitment to the lung during E. coli infection. E. coli induces MCP-1 through the MD-2 signaling pathway, which involves Toll-like receptors. MCP-1 in turn regulates neutrophil recruitment directly via chemotaxis and indirectly through neutrophil chemokines, such as KC, MIP-2, as well as the cytokine TNF-α.
