Table 1.
Alteration in blood chemistry during Aeromonas hydrophila infection
| Blood component (unit) | Mean concn ± SDd |
|||
|---|---|---|---|---|
| Vehiclea | AHLsa | Vehicle + A. hydrophilab | AHLs + A. hydrophilac | |
| ALB (g/dl) | 3.82 ± 0.2 | 3.78 ± 0.2 | 3.46 ± 0.3 | 2.94 ± 0.6 |
| ALP (U/liter) | 142.8 ± 36.8 | 136.4 ± 30.1 | 89.4 ± 13.9 | 77 ± 26.8 |
| ALT (U/liter) | 51 ± 11.3 | 42 ± 7.3 | 76.6 ± 18.4 | 48.8 ± 12.8 |
| AMY (U/liter) | 1,106 ± 372.9 | 1,149 ± 230.5 | 1,543.6 ± 486.8 | 1,092.6 ± 173.1 |
| TBIL (mg/dl) | 0.2 ± 0.0 | 0.22 ± 0.0 | 0.2 ± 0.0 | 0.2 ± 0.0 |
| BUN (mg/dl) | 14.2 ± 1.8 | 17.4 ± 6.0 | 14.2 ± 3.6 | 10.6 ± 2.8 |
| CA (mg/dl) | 12.3 ± 0.7 | 12.88 ± 0.6 | 12.04 ± 0.1 | 11.36 ± 0.2 |
| PHOS (mg/dl) | 12.14 ± 0.6 | 12.56 ± 1.0 | 16.06 ± 1.6 | 13.84 ± 1.5 |
| CRE (mg/dl) | 0.26 ± 0.1 | 0.22 ± 0.0 | 0.2 ± 0.0 | 0.2 ± 0.0 |
| GLU (mg/dl) | 390.2 ± 44.0 | 375.6 ± 102.6 | 226.4 ± 21.7 | 389.4 ± 122.9 |
| Na+ (mmol/liter) | 154 ± 1.2 | 154.2 ± 3.0 | 155.2 ± 1.6 | 152.8 ± 4.1 |
| K+ (mmol/liter) | 7.6 ± 1.0 | 7.68 ± 1.0 | 8.14 ± 0.4 | 7.6 ± 1.5 |
| TP (g/dl) | 5.2 ± 0.3 | 5.44 ± 0.3 | 4.78 ± 0.2 | 4.36 ± 0.8 |
| GLOB (g/dl) | 1.36 ± 0.2 | 1.7 ± 0.1 | 1.34 ± 0.1 | 1.4 ± 0.2 |
a
Blood chemistry was analyzed for mice that were treated only with vehicle or AHLs at 12 h and 6 h without A. hydrophila infection.
b
Blood chemistry was analyzed for mice that were treated with vehicle at 12 h and 6 h before challenge with A. hydrophila (3 × 107 CFU). Blood was collected at 4 h postinfection.
c
Blood chemistry was analyzed for mice that were treated with C4-HSL and C6-HSL in combination at 12 h and 6 h before challenge with A. hydrophila (3 × 107 CFU). Blood was collected at 4 h postinfection.
d
Data are shown as average mean values of five mice, and standard deviations (SDs) were determined.