Table 3.
Up- and downregulated genes in the ΔslyA mutant
| Category and locus | Gene product function | Fold change in expression |
|---|---|---|
| Protein synthesis | ||
| EF_3203 | Ribosomal protein L33 | +2.04 |
| Protein fate | ||
| EF_2524 | Sortase family protein | −2.55 |
| EF_2997 | Peptidase, M20M25M40 family | +3.81 |
| Phage | ||
| EF_0309 | Excisionase, putative | −2.27 |
| EF_1455 | Terminase, large subunit, putative | −2.04 |
| DNA metabolism | ||
| EF_1435 | Recombination protein U, putative | −2.15 |
| EF_2546 | Recombinase, phage integrase family | −2.48 |
| Cell envelope and cell division | ||
| EF_2533 | FtsK-SpoIIIE family protein | −2.24 |
| Transport and binding protein | ||
| EF_0758 | Cadmium-translocating P-type ATPase | −2.16 |
| EF_0893 | Amino acid ABC transporter | −2.97 |
| EF_3137 | PTS system, IIB component | −2.17 |
| EF_3138 | PTS system, IID component | −2.53 |
| EF_3139 | PTS system, IIC component | −3.06 |
| EF_3208 | ABC transporter, permease protein | −2.53 |
| EF_3209 | ABC transporter, ATP binding protein | −2.18 |
| Regulatory and DNA integration | ||
| EF_0102 | Transcriptional regulator, ArgR family | −2.71 |
| EF_0103 | Transcriptional regulator, ArgR family | −3.49 |
| EF_0307 | Transcriptional regulator, CroCI family | −2.78 |
| EF_0317 | Transcriptional regulator, CroCI family | −2.16 |
| EF_0719 | Transcriptional regulator, DeoR family | +2.19 |
| EF_1423 | Transcriptional regulator, CroCI family | −2.25 |
| EF_1450 | Positive control factor, putative | −2.05 |
| EF_2138 | Transcriptional regulator, CroCI family | −2.53 |
| EF_2141 | Transcriptional regulator, CroCI family | −2.45 |
| EF_2528 | Transcriptional regulator, CroCI family | −2.35 |
| Nucleotide metabolism | ||
| EF_1783 | Phosphoribosylformylglycinamidine synthetase I | −3.55 |
| EF_1784 | Phosphoribosylformylglycinamidine synthase, PurS protein | −3.76 |
| EF_1785 | Phosphoribosylaminoimidazole-succinocarboxamide synthase | −3.80 |
| EF_1786 | Phosphoribosylaminoimidazole carboxylase, ATPase subunit | −2.39 |
| Energy metabolism | ||
| EF_0271 | Glycosyl hydrolase, family 1 | −2.43 |
| EF_0696 | Tagatose 1,6-diphosphate aldolase | −2.03 |
| EF_0718 | 1-Phosphofructokinase | +3.12 |
| EF_1603 | Sucrose-6-phosphate dehydrogenase | −2.07 |
| Other metabolism | ||
| EF_0312 | Aspartate 1-decarboxylase domain protein | −2.54 |
| EF_0759 | SapB protein, putative | −2.31 |
| EF_1434 | DnaD domain protein | −2.06 |
| EF_3001 | Protease synthase and sporulation negative | +16.62 |
| EF_3217 | Helicase, putative | −32.24 |
| Virulence | ||
| EF_0149 | Aggregation substance, putative | −2.10 |
| EF_1426 | VrII protein, putative | −2.70 |
| Unknown | ||
| EF_0131/EF_1085/EF_1451 | Conserved domain protein | −2.01 to 3.07 |
| EF_0135/EF_0142/EF_0308/EF_0315/EF_0326/EF_0328/EF_0329/EF_1081/EF_1456EF_1459/EF_1466/EF_1467/EF_1470/EF_1471/ EF_1485/EF_1533/EF_2140/EF_2220EF_2519/EF_2520/EF_2521/ EF_2529/EF_2534/EF_2536/EF_2951/EF_2996 | Conserved hypothetical protein | ±2.00 to 2.83 |
| EF_0132/EF_0134/EF_0310/EF_0311/EF_0313/EF_0314/EF_0316/ EF_0320/EF_0327/EF_1015EF_1067/EF_1083/EF_1278/EF_1418/ EF_1424/EF_1425/EF_1427/EF_1428/EF_1429/EF_1431EF_1439/ EF_1458/EF_1489/EF_1686/EF_1812/EF_1988/EF_2133/EF_2135/ EF_2136/EF_2139EF_2523/EF_2526/EF_2530/EF_2531/EF_2532/ EF_2537/EF_2538/EF_2539/EF_2540/EF_2541EF_2542/EF_2942/ EF_2944/EF_2945/EF_2949/EF_2950/EF_2952/EF_2953 | Hypothetical protein | −2.00 to 3.36 |