Table 3.
Constitutive and induced expression of antimicrobial peptides in human skin in persistent carriers of Staphylococcus aureus
| AMP and expression | mRNA ratioa (95% CIb) in carriers vs noncarriers | P value for mRNA ratioc | Crude OR (95% CI)d | P value for crude ORd | Adjusted OR (95% CI) | P value for adjusted OR |
|---|---|---|---|---|---|---|
| HBD-3 | ||||||
| Constitutive | 0.76 (0.52–1.10) | 0.14 | 1.47 (0.87–2.47) | 0.15 | 1.59 (0.92–2.74)e | 0.1e |
| Induced | 0.63 (0.43–0.94) | 0.02 | 1.83 (1.05–3.18) | 0.03 | 1.97 (1.09–3.56)f | 0.025f |
| Rnase 7 | ||||||
| Constitutive | 0.84 (0.56–1.26) | 0.4 | 1.23 (0.78–1.95) | 0.4 | 1.29 (0.80–2.07)e | 0.3e |
| Induced | 0.84 (0.56–1.27) | 0.4 | 1.22 (0.78–1.92) | 0.4 | 1.22 (0.76–1.94)f | 0.4f |
a
The ratio is 2−mean ΔΔCT and compares expression levels of AMP mRNA in specimens of healthy skin (constitutive expression) and experimental sterile wounded skin (induced expression) of 30 persistent S. aureus nasal carriers relative to 30 noncarriers.
b
CI, confidence interval.
c
From unpaired, two-sided t test for the null hypothesis: expression is the same in carriers and noncarriers.
d
From univariable logistic regression.
e
From multivariable logistic regression adjusting for history of pyoderma.
f
From multivariable logistic regression adjusting for IgE serum levels and age.