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Scope of HNR1R2 in enantioselective synthesis of (S)-β-fluoroamines.
 | |||
|---|---|---|---|
| compda | product | yield (%)b | ee (%)c |
| 7a |  |
80 | >99 (S) |
| 7b |  |
70 | >98 (S) |
| 7c |  |
76 | >99 (S) |
| 7d |  |
69 | >98 (S) |
| 7e |  |
65 | >96 (S) |
| 7f |  |
82 | >95 (S) |
All reactions were performed on a 0.5 mmol scale and proceeded to complete conversion.
Yield after chromatography.
Enantiomeric excess were determined using chiral stationary phase
